The University of Chicago Header Logo

Search Result Details

Back to Search Results
This page shows the details of why an item matched the keywords from your search.
Search Results
Saygin, Caner
One or more keywords matched the following properties of Saygin, Caner
PropertyValue
overview Saygin Lab studies leukemia biology by using in vitro and in vivo models of acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL), as well as human samples obtained from patients with leukemia. We are particularly interested in drivers of CHIP (clonal hematopoiesis of indeterminate potential) progression to leukemias of myeloid vs lymphoid lineage in de novo and therapy-related leukemogenesis. Our translational research lab aims to identify mechanisms driving these fatal diseases and leverage them for new experimental therapeutics. Our drug development efforts focusing on high-risk subsets of AML and ALL have led to “home-grown” phase I/II investigator-initiated clinical trials.
One or more keywords matched the following items that are connected to Saygin, Caner
Item TypeName
Concept Aged, 80 and over
Concept Adolescent
Concept Aged
Concept Adrenergic beta-Antagonists
Concept Adult
Concept Animals
Concept Cell Differentiation
Concept Cell Nucleus
Concept Behcet Syndrome
Concept Blood Transfusion
Concept Bone Marrow
Concept Child
Concept Clone Cells
Concept Dendritic Cells
Concept Child, Preschool
Concept Hematopoietic Stem Cells
Concept Infant
Concept Germ Cells
Concept Middle Aged
Concept Molecular Biology
Concept Smoking
Concept Humans
Concept Protein Biosynthesis
Concept Biomarkers, Tumor
Concept Clinical Trials, Phase I as Topic
Concept Biomarkers
Concept Leukemia, Lymphocytic, Chronic, B-Cell
Concept Hematopoietic Stem Cell Transplantation
Concept Lymphoma
Concept Drug Approval
Concept Clinical Trials, Phase II as Topic
Concept Mice, Knockout
Concept beta Catenin
Concept BRCA1 Protein
Concept Embryonic Stem Cells
Concept Total Quality Management
Concept Tumor Burden
Concept Proto-Oncogene Proteins c-bcl-2
Concept BRCA2 Protein
Concept bcl-X Protein
Concept Mice
Concept Surveys and Questionnaires
Concept Socioeconomic Factors
Concept Quality Improvement
Concept Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Concept Lymphoma, B-Cell
Concept Lymphoma, T-Cell
Concept Lymphoma, Large B-Cell, Diffuse
Concept Precursor Cell Lymphoblastic Leukemia-Lymphoma
Concept Workflow
Concept Basic Helix-Loop-Helix Transcription Factors
Concept Cell Line, Tumor
Concept Back Pain
Concept Biological Factors
Concept Lymphoma, Non-Hodgkin
Concept Neoplastic Stem Cells
Concept Lymphoma, T-Cell, Peripheral
Concept Mice, SCID
Concept Mice, Inbred NOD
Concept Young Adult
Academic Article Therapy-related acute lymphoblastic leukemia is a distinct entity with adverse genetic features and clinical outcomes.
Academic Article OTS167 blocks FLT3 translation and synergizes with FLT3 inhibitors in FLT3 mutant acute myeloid leukemia.
Academic Article Cedazuridine/decitabine: from preclinical to clinical development in myeloid malignancies.
Academic Article Genetics of Myelodysplastic Syndromes.
Academic Article B-cell lymphoma-2 downregulation is a useful feature supporting a neoplastic phenotype in mature T-cell lymphomas.
Academic Article Measurable residual disease in acute lymphoblastic leukemia: methods and clinical context in adult patients.
Academic Article Paired bone marrow and peripheral blood samples demonstrate lack of widespread dissemination of some CH clones.
Academic Article Allogeneic hematopoietic stem cell transplant outcomes in adults with inherited myeloid malignancies.
Concept Cell Self Renewal
Concept MCF-7 Cells
Concept Myeloid Cell Leukemia Sequence 1 Protein
Concept Triple Negative Breast Neoplasms
Academic Article Loss of thymocyte competition underlies the tumor suppressive functions of the E2a transcription factor in T lymphocyte acute lymphoblastic leukemia.
Academic Article Dual Targeting of Apoptotic and Signaling Pathways in T-Lineage Acute Lymphoblastic Leukemia.
Academic Article Suicidal ideation among patients with Behçet's syndrome.
Academic Article New Advances and Challenges of Targeting Cancer Stem Cells.
Academic Article LC-FACSeq is a method for detecting rare clones in leukemia.
Academic Article A 17-year experience with ALL-BFM protocol in acute lymphoblastic leukemia: prognostic predictors and interruptions during protocol.
Academic Article Cytopenias After CD19 Chimeric Antigen Receptor T-Cells (CAR-T) Therapy for Diffuse Large B-Cell Lymphomas or Transformed Follicular Lymphoma: A Single Institution Experience.
Academic Article Dendritic cell sarcoma: a pooled analysis including 462 cases with presentation of our case series.
Academic Article Thy-1 predicts poor prognosis and is associated with self-renewal in ovarian cancer.
Academic Article The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms.
Academic Article No appreciable decrease in fertility in Behçet's syndrome.
Academic Article Impact of comorbidities on outcomes of elderly patients with diffuse large B-cell lymphoma.
Academic Article From cell surface to nucleus: CCRL2 regulates response to hypomethylating agents in myelodysplastic syndromes.
Academic Article Cisplatin induces stemness in ovarian cancer.
Academic Article Reporter Systems to Study Cancer Stem Cells.
Academic Article Prognostic impact of incomplete hematologic count recovery and minimal residual disease on outcome in adult acute lymphoblastic leukemia at the time of second complete response.
Academic Article Mutations in DNMT3A, U2AF1, and EZH2 identify intermediate-risk acute myeloid leukemia patients with poor outcome after CR1.
Academic Article Outcomes of the cyclophosphamide, vincristine, prednisone (CVP) +/- rituximab (R-CVP) regimen in older patients with newly diagnosed Ph- acute lymphoblastic leukemia.
Academic Article Therapy for lower-risk MDS.
Academic Article Current and emerging strategies for management of myelodysplastic syndromes.
Academic Article Novel use of propranolol for management of pain in children with vertebral hemangioma: report of two cases.
Academic Article Primary central nervous system lymphoma in immunocompetent individuals: a single center experience.
Academic Article Expression of MMP-1, MMP-9 and TIMP-2 in prostate carcinoma and their influence on prognosis and survival.
Academic Article Currently Used Biologic Agents in the Management of Behcet's Syndrome.
Academic Article Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase.
Academic Article Targeting Cancer Stemness in the Clinic: From Hype to Hope.
Academic Article Genomic analysis of cellular hierarchy in acute myeloid leukemia using ultrasensitive LC-FACSeq.
Academic Article Epithelial-Mesenchymal Transition Markers ß-catenin, Snail, and E-Cadherin do not Predict Disease Free Survival in Prostate Adenocarcinoma: a Prospective Study.
Academic Article CD55 regulates self-renewal and cisplatin resistance in endometrioid tumors.
Academic Article Socioeconomic determinants of the biology and outcomes of acute lymphoblastic leukemia in adults.
Academic Article Sequential tumor molecular profiling identifies likely germline variants.
Academic Article Durable responses in acute lymphoblastic leukaemia with the use of FLT3 and IDH inhibitors.
Academic Article Acute lymphoblastic leukemia with myeloid mutations is a high-risk disease associated with clonal hematopoiesis.
Academic Article Loss of thymocyte competition underlies the tumor suppressive functions of the E2a transcription factor in T-ALL.
Academic Article Treatment outcomes of venetoclax-combination regimens for relapsed/refractory myeloid malignancies after anti-CD47-directed therapy.
Search Criteria
  • Lymphoma
  • Large
  • B
  • Cell
  • Diffuse